Current strategies in antibody engineering: Fc engineering and pH-dependent antigen binding, bispecific antibodies and antibody drug conjugates
Author:
Publisher
Wiley
Subject
Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/biot.201200250/fullpdf
Reference38 articles.
1. Engineered antibody Fc variants with enhanced effector function.;Lazar;Proc. Natl. Acad. Sci. USA,2006
2. High resolution mapping of the binding site on human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and design of IgG1 variants with improved binding to the FcγR.;Shields;J. Biol. Chem.,2001
3. Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fc? receptors.;Stavenhagen;Cancer Res.,2007
4. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity.;Moessner;Blood.,2010
5. Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: A multicenter Phase II study.;Ishida;J. Clin. Oncol.,2012
Cited by 47 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Modeling Chromatography Binding through Molecular Dynamics Simulations with Resin Fragments;The Journal of Physical Chemistry B;2024-05-29
2. Generation of bispecific antibodies by structure-guided redesign of IgG constant regions;Frontiers in Immunology;2023-01-10
3. The manufacturing considerations of bispecific antibodies;Expert Opinion on Biological Therapy;2022-07-06
4. Modeling Pharmacokinetics and Pharmacodynamics of Therapeutic Antibodies: Progress, Challenges, and Future Directions;Pharmaceutics;2021-03-21
5. Quantifying Protein–Protein Interactions by Molecular Counting with Mass Photometry;Angewandte Chemie International Edition;2020-04-02
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3