Generation of High Expressing Chinese Hamster Ovary Cell Pools Using the Leap-In Transposon System-Reference-Cited by-同舟云学术

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Generation of High Expressing Chinese Hamster Ovary Cell Pools Using the Leap-In Transposon System

Published:2018-06-11 Issue:10 Volume:13 Page:1700748
ISSN:1860-6768
Container-title:Biotechnology Journal
language:en
Short-container-title:Biotechnol. J.

Author:

Balasubramanian Sowmya¹,Peery Robert B.²,Minshull Jeremy³,Lee Maggie³,White Regina²,Kelly Ronan M.¹,Barnard Gavin C.²

Affiliation:

1. Bioprocess Research and Development; Eli Lilly and Company; LTC-North, 1200 Kentucky AvenueIndianapolis IN 46221 USA

2. Biotechnology Discovery Research; Lilly Research Laboratories; Eli Lilly and Company; Lilly Corporate Center; Indianapolis IN 46225 USA

3. ATUM; 37950 Central CtNewark CA 94560 USA

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/biot.201700748/fullpdf

Reference25 articles.

1. Production of recombinant protein therapeutics in cultivated mammalian cells

2. Cloning of CHO Cells, Productivity and Genetic Stability—A Discussion

3. Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time

4. Industry view on the relative importance of “clonality” of biopharmaceutical-producing cell lines

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1. The new frontier in CHO cell line development: From random to targeted transgene integration technologies;Biotechnology Advances;2024-10

2. Recombinant Antibody-Producing Stable CHOK1 Pool Stability Study;Monoclonal Antibodies in Immunodiagnosis and Immunotherapy;2024-08-01

3. Evaluation of two transposases for improving expression of recombinant proteins in Chinese hamster ovary cell stable pools by co‐transfection and supertransfection approaches;Biotechnology Progress;2024-07-17

4. Development of a 10 g/L process for a difficult-to-express multispecific antibody format using a holistic process development approach;Journal of Biotechnology;2024-06

5. Therapeutic proteins: developments, progress, challenges, and future perspectives;3 Biotech;2024-03-18

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