Transient Expression of Human Cytochrome P450s 2D6 and 3A4 in Nicotiana benthamiana Provides a Possibility for Rapid Substrate Testing and Production of Novel Compounds
Author:
Affiliation:
1. Plant Biotechnology and Metabolic Engineering; Technische Universität Darmstadt; Darmstadt 64287 Germany
2. Institute of Cell Biology and Genetic Engineering; National Academy of Science of Ukraine; 03143 Kiev Ukraine
Funder
Alexander von Humboldt-Stiftung
Publisher
Wiley
Subject
Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/biot.201700696/fullpdf
Reference46 articles.
1. Transient Expression Systems in Plants: Potentialities and Constraints
2. A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules
3. What makes a P450 tick?
4. SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions
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1. Solar-powered P450 catalysis: Engineering electron transfer pathways from photosynthesis to P450s;Journal of Inorganic Biochemistry;2023-08
2. Evaluation of biotransformation capacity of transplastomic plants and hairy roots of Nicotiana tabacum expressing human cytochrome P450 2D6;Transgenic Research;2022-04-13
3. Developmental Pharmacogenetics of CYP2D6 in Chinese Children: Loratadine as a Substrate Drug;Frontiers in Pharmacology;2021-07-06
4. Expanding the Diversity of Plant Monoterpenoid Indole Alkaloids Employing Human Cytochrome P450 3A4;ChemBioChem;2020-04-06
5. Altered fatty acid composition of Nicotiana benthamiana and Nicotiana excelsior leaves under transient overexpression of the cyanobacterial desC gene;Biologia plantarum;2020-02-28
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