Integrated Genome and Protein Editing Swaps α ‐2,6 Sialylation for α ‐2,3 Sialic Acid on Recombinant Antibodies from CHO
Author:
Affiliation:
1. Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD USA
2. Department of Pathology Johns Hopkins University Baltimore MD USA
Funder
National Science Foundation
Publisher
Wiley
Subject
Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.201600502
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4. Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity
5. Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities
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