A Study to Assess the Proarrhythmic Potential of Mirtazapine Using Concentration-QTc (C-QTc) Analysis
Author:
Affiliation:
1. Merck & Co., Inc.; Kenilworth NJ USA
2. Present affiliation: OrbiMed Advisors LLC; San Francisco CA USA
3. Present affiliation: Janssen Pharmaceuticals; Spring House PA USA
Funder
Merck Sharp and Dohme
Publisher
Wiley
Subject
Pharmacology (medical),Pharmaceutical Science
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/cpdd.605/fullpdf
Reference25 articles.
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2. Torsade de pointes;Roden;Clin Cardiol,1993
3. Taking the “idio” out of “idiosyncratic”: predicting torsades de pointes;Roden;Pacing Clin Electrophysiol,1998
4. Spontaneous adverse event reports of serious ventricular arrhythmias, QT prolongation, syncope, and sudden death in patients treated with cisapride;Barbey;J Cardiovasc Pharmacol Ther,2002
5. Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences;Honig;JAMA,1993
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