Co-administration of N-Acetylcysteine and Acetaminophen Efficiently Blocks Acetaminophen Toxicity

Author:

Owumi Solomon E1,Andrus James P2,Herzenberg Leonard A1,Herzenberg Leonore A1

Affiliation:

1. Department of Genetics; Stanford University School of Medicine, B007 Beckman Center; 279 Campus Drive Stanford CA USA

2. Department of Pediatric Critical Care; Pediatrix Medical Group of Nevada; 3186 Maryland Pkwy Las Vegas NV USA

Publisher

Wiley

Subject

Drug Discovery

Reference23 articles.

1. Effects of legislation restricting pack sizes of paracetamol on self poisoning. Paracetamol should be packaged with its antidote;Andrus;BMJ,2001

2. 2009. Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th annual report;Bronstein;Clin Toxicol (Phila),2010

3. Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice;Corcoran;J Pharmacol Exp Ther,1985

4. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning;Dawson;Med J Aust,1989

5. N-acetylcysteine replenishes glutathione in HIV infection;Rosa;Eur J Clin Invest,2000

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