Genetic characterisation of canine adenovirus type 1 in an 18‐month‐old mixed breed male dog and its effect on clinico‐pathology, hemato‐biochemistry and serum oxidant–antioxidant status

Author:

Chakraborty Pradyumna1,Behera Suvendu Kumar2ORCID,Arya Rahul Singh3,Maibam Leibaknganbi2,Lalhriatchhungi Mary H.1

Affiliation:

1. Department of Veterinary Medicine West Bengal University of Animal & Fishery Sciences Kolkata West Bengal India

2. Department of Veterinary Medicine College of Veterinary Sciences and Animal Husbandry Central Agricultural University Aizawl Mizoram India

3. Department of Veterinary Pathology College of Veterinary Sciences and Animal Husbandry Central Agricultural University Aizawl Mizoram India

Abstract

AbstractAn 18‐month‐old, mixed breed male dog was presented with hypothermia, recumbency, hematemesis, melena, and moribund condition, and screened by rapid antigen detection kit followed by polymerase chain reaction confirmation for canine adenovirus type 1 infection. The phylogenetic analysis of the sequence revealed clustering with Indian, Spanish, Italian, Portuguese, Chinese, and Australian sequences with amino acid homology of 98.81%–100%. There was a mutation (N127D) in the E3 protein encoding sequence, which was hitherto reported only in one Indian (GQ340423) sequence. Haemogram revealed anaemia, neutropenic leukopenia, and thrombocytopenia. Serum biochemistry revealed marked hyperglycaemia, hypoproteinemia, hypoalbuminemia, and an increase in the activities of hepatic enzymes. Serum oxidant antioxidant parameters revealed a marked increase in the level of oxidant and a decreased level of antioxidants. Postmortem examination revealed multifocal necrotic patches in the liver, marked haemorrhage in the stomach and intestines, emphysematous lungs, splenomegaly, and congested kidney. Histopathology revealed necrohaemorrhagic hepatitis and intranuclear inclusion bodies in the hepatocytes and glomerular degeneration.

Publisher

Wiley

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