Prediagnostic serum glyceraldehyde‐derived advanced glycation end products and mortality among colorectal cancer patients-Reference-Cited by-同舟云学术

Prediagnostic serum glyceraldehyde‐derived advanced glycation end products and mortality among colorectal cancer patients

Published:2023-03-20 Issue:11 Volume:152 Page:2257-2268
ISSN:0020-7136
Container-title:International Journal of Cancer
language:en
Short-container-title:Intl Journal of Cancer

Author:

Mao Ziling¹²,Baker Jacqueline Roshelli¹,Takeuchi Masayoshi³,Hyogo Hideyuki⁴⁵,Tjønneland Anne⁶⁷,Eriksen Anne Kirstine⁶,Severi Gianluca⁸⁹^ORCID,Rothwell Joseph⁸,Laouali Nasser⁸,Katzke Verena¹⁰,Kaaks Rudolf¹⁰,Schulze Matthias B.¹¹¹²,Palli Domenico¹³^ORCID,Sieri Sabina¹⁴^ORCID,de Magistris Maria Santucci¹⁵,Tumino Rosario¹⁶,Sacerdote Carlotta¹⁷^ORCID,Derksen Jeroen W. G.¹⁸,Gram Inger T.¹⁹^ORCID,Skeie Guri¹⁹,Sandanger Torkjel M.¹⁹,Quirós Jose Ramón²⁰,Crous‐Bou Marta²¹²²,Sánchez Maria‐Jose²³²⁴²⁵²⁶,Amiano Pilar²⁵²⁷²⁸,Colorado‐Yohar Sandra M.²⁵²⁹³⁰,Guevara Marcela²⁵³¹³²,Harlid Sophia³³^ORCID,Johansson Ingegerd³⁴,Perez‐Cornago Aurora³⁵,Freisling Heinz³⁶^ORCID,Gunter Marc³⁶,Weiderpass Elisabete³⁷,Heath Alicia K.³⁸^ORCID,Aglago Elom³⁸^ORCID,Jenab Mazda³⁶^ORCID,Fedirko Veronika¹³⁹^ORCID

Affiliation:

1. Department of Epidemiology, Rollins School of Public Health Emory University Atlanta Georgia USA

2. Department of Epidemiology, Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA

3. Department of Advanced Medicine Medical Research Institute, Kanazawa Medical University Ishikawa Japan

4. Department of Gastroenterology and Metabolism Hiroshima University Hospital Hiroshima Japan

5. Lifecare Clinic Hiroshima Hiroshima Japan

6. Danish Cancer Society Research Center, Diet, Cancer and Health Copenhagen Denmark

7. Department of Public Health University of Copenhagen Copenhagen Denmark

8. UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team Université Paris‐Saclay Villejuif France

9. Department of Statistics, Computer Science Applications “G. Parenti” University of Florence Florence Italy

10. Division of Cancer Epidemiology German Cancer Research Center (DKFZ) Heidelberg Germany

11. Department of Molecular Epidemiology German Institute of Human Nutrition Potsdam‐Rehbruecke Nuthetal Germany

12. Institute of Nutritional Science, University of Potsdam Nuthetal Germany

13. Cancer Risk Factors and Life‐Style Epidemiology Unit Institute for Cancer Research, Prevention and Clinical Network – ISPRO Florence Italy

14. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Via Venezian Milan Italy

15. Azienda Ospedaliera Universitaria Federico II Naples Italy

16. Hyblean Association for Epidemiological Research, AIRE ONLUS Ragusa Italy

17. Unit of Cancer Epidemiology Città della Salute e della Scienza University‐Hospital Turin Italy

18. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht Utrecht University Utrecht The Netherlands

19. Department of Community Medicine UiT‐The Arctic University of Norway Tromsø Norway

20. Public Health Directorate Asturias Spain

21. Unit of Nutrition and Cancer, Cancer Epidemiology Research Program Catalan Institute of Oncology (ICO) ‐ Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat Barcelona Spain

22. Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts USA

23. Escuela Andaluza de Salud Pública (EASP) Granada Spain

24. Instituto de Investigación Biosanitaria ibs.GRANADA Granada Spain

25. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) Madrid Spain

26. Department of Preventive Medicine and Public Health University of Granada Granada Spain

27. Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa San Sebastian Spain

28. Epidemiology of Chronic and Communicable Diseases Group Biodonostia Health Research Institute San Sebastián Spain

29. Department of Epidemiology Murcia Regional Health Council, IMIB‐Arrixaca Murcia Spain

30. Research Group on Demography and Health, National Faculty of Public Health University of Antioquia Medellín Colombia

31. Navarra Public Health Institute Pamplona Spain

32. Navarra Institute for Health Research (IdiSNA) Pamplona Spain

33. Department of Radiation Sciences Umeå University Umeå Sweden

34. Department of Odontology Umeå university Umeå Sweden

35. Cancer Epidemiology Unit (CEU), Nuffield Department of Population Health, Medical Sciences Division University of Oxford Oxford UK

36. Section of Nutrition and Metabolism, Nutritional Epidemiology Group International Agency for Research on Cancer, World Health Organization (IARC‐WHO) Lyon France

37. Office of the Director, International Agency for Research on Cancer (IARC‐WHO) Lyon France

38. Department of Epidemiology and Biostatistics, School of Public Health Imperial College London London UK

39. MD Anderson Cancer Center Houston Texas USA

Abstract

AbstractGlyceraldehyde‐derived advanced glycation end products (glycer‐AGEs) could contribute to colorectal cancer development and progression due to their pro‐oxidative and pro‐inflammatory properties. However, the association of glycer‐AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer‐AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer‐AGEs concentrations with CRC‐specific and all‐cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow‐up, 529 participants died (409 from CRC). Glycer‐AGEs were statistically significantly positively associated with CRC‐specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04‐2.25, Ptrend = .002) and all‐cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16‐2.26, Ptrend < .001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer‐AGEs and CRC‐specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74‐1.42; HRdistal colon = 1.51, 95% CI: 1.20‐1.91; Peffect modification = .02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer‐AGEs category relative to lowest BMI and glycer‐AGEs category for both CRC‐specific (HR = 1.78, 95% CI: 1.02‐3.01) and all‐cause mortality (HR = 2.15, 95% CI: 1.33‐3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer‐AGEs are positively associated with CRC‐specific and all‐cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.

Funder

Cancer Prevention and Research Institute of Texas

Wereld Kanker Onderzoek Fonds

Centre International de Recherche sur le Cancer

Imperial College London

NIHR Imperial Biomedical Research Centre

Kræftens Bekæmpelse

Ligue Contre le Cancer

Mutuelle Générale de l'Education Nationale

Institut National de la Santé et de la Recherche Médicale

Deutsche Krebshilfe

Deutsches Krebsforschungszentrum

Bundesministerium für Bildung und Forschung

National Research Council

Ministerie van Volksgezondheid, Welzijn en Sport

World Cancer Research Fund

Instituto de Salud Carlos III

Cancerfonden

Vetenskapsrådet

Medical Research Council

Cancer Research UK

Publisher

Wiley

Subject

Cancer Research,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.34449

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