Characterization of acidic and basic variants of IgG1 therapeutic monoclonal antibodies based on non-denaturing IEF fractionation
Author:
Affiliation:
1. Department of Analytical Sciences; Seattle Genetics Inc; Bothell WA USA
Publisher
Wiley
Subject
Clinical Biochemistry,Biochemistry,Analytical Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/elps.201500219/fullpdf
Reference38 articles.
1. Using antibodies to target cancer therapeutics
2. Full-length antibodies on display
3. Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture
4. Identification of multiple sources of charge heterogeneity in a recombinant antibody
5. Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain
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