Capillary electrochromatography-mass spectrometry for the determination of 5-nitroimidazole antibiotics in urine samples
Author:
Affiliation:
1. Istituto di Metodologie Chimiche; Consiglio Nazionale delle Ricerche; Monterotondo Italy
2. Department of Analytical Chemistry, Faculty of Sciences; University of Granada; Granada Spain
Publisher
Wiley
Subject
Clinical Biochemistry,Biochemistry,Analytical Chemistry
Reference43 articles.
1. Metronidazole Is Still the Drug of Choice for Treatment of Anaerobic Infections
2. Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance
3. Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia
4. Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity
5. Concentrations of metronidazole in human plasma and saliva after tablet or gel administration
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