Minimum required signal-to-noise ratio for optimal precision in HPLC and CE

Author:

Meyer Christoph1,Seiler Patricia1,Bies Celine1,Cianciulli Claudia2,Wätzig Hermann2,Meyer Veronika R.3

Affiliation:

1. Novartis Pharma AG; Basel; Switzerland

2. Institute for Medical and Pharmaceutical Chemistry; Technical University of Braunschweig; Braunschweig; Germany

3. Empa St. Gallen; Swiss Federal Laboratories for Materials Science and Technology; St. Gallen; Switzerland

Publisher

Wiley

Subject

Clinical Biochemistry,Biochemistry,Analytical Chemistry

Reference33 articles.

1. Base-line noise and detection limits in signal-integrating analytical methods. Application to chromatography

2. Prediction of precision from signal and noise measurement in liquid chromatography: Limit of detection

3. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, Validation of Analytical Procedures Text and Methodology 2005 http://www.ich.org/products/guidelines/quality/article/quality-guidelines.html

4. Dong , M. W. Views (Perkin-Elmer Newsletter), Fall 1994 7 8

5. BIS repetita non placent—a statistical analysis of the number of sample preparations and number of injections required for chromatographic analyses

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