In vivo quantification of glial activation in minipigs overexpressing human α-synuclein

Author:

Lillethorup Thea Pinholt1ORCID,Glud Andreas Nørgaard2ORCID,Landeck Natalie3,Alstrup Aage Kristian Olsen1,Jakobsen Steen1,Vang Kim1,Doudet Doris J.14,Brooks David J.156,Kirik Deniz3,Hinz Rainer7,Sørensen Jens Christian2,Landau Anne M.18ORCID

Affiliation:

1. Department of Nuclear Medicine and PET Center; Institute of Clinical Medicine, Aarhus University and Hospital; Aarhus Denmark

2. Center for Experimental Neuroscience (CENSE), Department of Neurosurgery; Institute of Clinical Medicine, Aarhus University; Aarhus Denmark

3. Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Science; Lund University; Lund Sweden

4. Department of Medicine/Neurology; University of British Columbia; Vancouver British Columbia Canada

5. Division of Neuroscience, Department of Medicine; Imperial College London; London United Kingdom

6. Division of Neuroscience; Newcastle University; Newcastle United Kingdom

7. Wolfson Molecular Imaging Centre; University of Manchester; Manchester United Kingdom

8. Translational Neuropsychiatry Unit; Institute of Clinical Medicine, Aarhus University; Risskov Denmark

Funder

Lundbeckfonden

FP7 Health

Parkinsonforeningen

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

Reference67 articles.

1. PET radioligand injection for pig neuroimaging;Alstrup;Scandinavian Journal of Laboratory Animal Science,2018

2. Visualising microglial activation in vivo;Banati;Glia,2002

3. Long-term polarization of microglia upon alpha-synuclein overexpression in nonhuman primates;Barkholt;Neuroscience,2012

4. Neuroinflammation in the pathophysiology of Parkinson's disease: Evidence from animal models to human in vivo studies with [11C]-PK11195 PET;Bartels;Movement Disorders,2007

5. The telencephalon of the Gottingen minipig, cytoarchitecture and cortical surface anatomy;Bjarkam;Brain Structure and Function,2017

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