Neurite growth could be impaired by ETFDH mutation but restored by mitochondrial cofactors

Author:

Liang Wen-Chen12,Lin Yen-Fong2,Liu Ting-Yuan3,Chang Shin-Cheng2,Chen Bai-Hsiun134,Nishino Ichizo56,Jong Yuh-Jyh1347

Affiliation:

1. Department of Pediatrics; Kaohsiung Medical University Hospital, Kaohsiung Medical University; Kaohsiung Taiwan

2. Department of Pediatrics, School of Medicine, College of Medicine; Kaohsiung Medical University; Kaohsiung Taiwan

3. Graduate Institute of Clinical Medicine, College of Medicine; Kaohsiung Medical University; Kaohsiung Taiwan

4. Department of Laboratory Medicine; Kaohsiung Medical University Hospital, Kaohsiung Medical University; Kaohsiung Taiwan

5. Department of Neuromuscular Research; National Institute of Neuroscience, National Center of Neurology and Psychiatry; Tokyo Japan

6. Department of Clinical Development, Translational Medical Center; National Center of Neurology and Psychiatry; Tokyo Japan

7. Department of Biological Science and Technology, College of Biological Science and Technology; National Chiao Tung University; Hsinchu Taiwan

Publisher

Wiley

Subject

Physiology (medical),Cellular and Molecular Neuroscience,Neurology (clinical),Physiology

Reference33 articles.

1. Molecular characterization of variant alpha-subunit of electron transfer flavoprotein in three patients with glutaric acidemia type II--and identification of glycine substitution for valine-157 in the sequence of the precursor, producing an unstable mature protein in a patient;Indo;Am J Hum Genet,1991

2. Glutaric acidemia type II. Heterogeneity in beta-oxidation flux, polypeptide synthesis, and complementary DNA mutations in the alpha subunit of electron transfer flavoprotein in eight patients;Freneaux;J Clin Invest,1992

3. Characterization of a mutation that abolishes quinone reduction by electron transfer flavoprotein-ubiquinone oxidoreductase;Beard;Hum Mol Genet,1995

4. Glutaric acidemia type II: gene structure and mutations of the electron transfer flavoprotein:ubiquinone oxidoreductase (ETF:QO) gene;Goodman;Mol Genet Metab,2002

5. Acyl-CoA dehydrogenases. A mechanistic overview;Ghisla;Eur J Biochem,2004

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