Affiliation:
1. Facultad de Ciencias Químicas Universidad Veracruzana Prolongación de Oriente 6, No. 1009, Col. Rafael Alvarado C.P. 94340 Orizaba, Veracruz México
2. Department of Nanotechnology INTESU Universidad Tecnológica del Centro de Veracruz México
3. Basic Science Department Metropolitan-Azcapotzalco Autonomous University (UAM) Av. San Pablo No 180, Col. Reynosa-Tamaulipas Ciudad de México 02200 México
4. Facultad de ingeniería Universidad Veracruzana, UV campus Ixtaczoquitlán carretera sumidero-dos ríos km 1. C.P. 94452 Veracruz México
Abstract
AbstractThis study explores various aspects of Metal‐Organic Frameworks (MOFs), focusing on synthesis techniques to adjust pore size and key ligands and metals for crafting carrier MOFs. It investigates MOF‐drug interactions, including hydrogen bonding, van der Waals, and electrostatic interactions, along with kinetic studies. The multifaceted applications of MOFs in drug delivery systems are elucidated. The morphology and structure of MOFs are intricately linked to synthesis methodology, impacting attributes like crystallinity, porosity, and surface area. Hydrothermal synthesis yields MOFs with high crystallinity, suitable for catalytic applications, while solvothermal synthesis generates MOFs with increased porosity, ideal for gas and liquid adsorption. Understanding MOF‐drug interactions is crucial for optimizing drug delivery, affecting charge capacity, stability, and therapeutic efficacy. Kinetic studies determine drug release rates and uniformity, vital for controlled drug delivery. Overall, comprehending drug‐MOF interactions and kinetics is essential for developing effective and controllable drug delivery systems.