Polysubstituted Pyrimidines as mPGES‐1 Inhibitors: Discovery of Potent Inhibitors of PGE 2 Production with Strong Anti‐inflammatory Effects in Carrageenan‐Induced Rat Paw Edema-Reference-Cited by-同舟云学术

Polysubstituted Pyrimidines as mPGES‐1 Inhibitors: Discovery of Potent Inhibitors of PGE 2 Production with Strong Anti‐inflammatory Effects in Carrageenan‐Induced Rat Paw Edema

Published:2020-06-04 Issue:15 Volume:15 Page:1398-1407
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Kalčic Filip¹²,Kolman Viktor¹,Ajani Haresh¹,Zídek Zdeněk³,Janeba Zlatko¹^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences Flemingovo nám. 2 166 10 Prague 6 Czech Republic

2. Department of Organic ChemistryFaculty of ScienceCharles University Hlavova 8 128 43 Prague 2 Czech Republic

3. Institute of Experimental Medicine of the Czech Academy of Sciences Vídeňská 1083 142 20 Prague 4 Czech Republic

Funder

Ústav organické chemie a biochemie Akademie věd České republiky

Technology Agency of the Czech Republic

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000258

Reference95 articles.

1. Nonsteroidal Anti-Inflammatory Therapy: A Journey Toward Safety

2. Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

3. Structural and Functional Basis of Cyclooxygenase Inhibition

4. Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

5. Gastrointestinal effects of nonsteroidal anti-inflammatory drugs

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