The Effects of Prodrug Size and a Carbonyl Linker on l ‐Type Amino Acid Transporter 1‐Targeted Cellular and Brain Uptake-Reference-Cited by-同舟云学术

The Effects of Prodrug Size and a Carbonyl Linker on l ‐Type Amino Acid Transporter 1‐Targeted Cellular and Brain Uptake

Published:2020-12-11 Issue:5 Volume:16 Page:869-880
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Venteicher Brooklynn¹,Merklin Kasey¹,Ngo Huy X.²,Chien Huan‐Chieh²,Hutchinson Keino³,Campbell Jerome¹,Way Hannah¹,Griffith Joseph¹,Alvarado Cesar¹,Chandra Surabhi⁴,Hill Evan⁵,Schlessinger Avner³,Thomas Allen A.¹^ORCID

Affiliation:

1. Department of Chemistry University of Nebraska at Kearney 2401 11th Ave, Bruner Hall of Science Kearney NE 68849 USA

2. Department of Bioengineering and Therapeutic Sciences University of California, San Francisco 1550 4th St, Rm RH581 San Francisco CA 94143 USA

3. Department of Pharmacological Sciences Icahn School of Medicine at Mt. Sinai 1468 Madison Ave, Annenberg Building Floor 19 New York NY 10029 USA

4. Department of Biology University of Nebraska at Kearney 2401 11th Ave, Bruner Hall of Science Kearney NE 68849 USA

5. Department of Psychology University of Nebraska at Kearney 2507 11th Ave, Copeland Hall Kearney NE 68849 (USA)

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000824

Reference70 articles.

2. Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation

3. Selective expression of the large neutral amino acid transporter at the blood-brain barrier

4. Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood-brain barrier

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