Design, Synthesis and Evaluation of a Series of 1,5‐Diaryl‐1,2,3‐triazole‐4‐carbohydrazones as Inhibitors of the YAP‐TAZ/TEAD Complex-Reference-Cited by-同舟云学术

Design, Synthesis and Evaluation of a Series of 1,5‐Diaryl‐1,2,3‐triazole‐4‐carbohydrazones as Inhibitors of the YAP‐TAZ/TEAD Complex

Published:2021-07 Issue:18 Volume:16 Page:2823-2844
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Gibault Floriane¹,Sturbaut Manon¹,Coevoet Mathilde¹,Pugnière Martine²,Burtscher Ashley³,Allemand Frédéric⁴,Melnyk Patricia¹^ORCID,Hong Wanjin⁵,Rubin Brian P.³,Pobbati Ajaybabu V.³,Guichou Jean‐François⁴,Cotelle Philippe¹⁶^ORCID,Bailly Fabrice¹^ORCID

Affiliation:

1. INSERM UMR-S 1172 Lille Neuroscience & Cognition University of Lille 59000 Lille France

2. Institut de Recherche en Cancérologie de Montpellier (IRCM) Institut Régional du Cancer de Montpellier (ICM) University of Montpellier 208 rue des Apothicaires 34298 Montpellier Cedex 5 France

3. Robert J. Tomsich Pathology and Laboratory Medicine Institute and Department of Cancer Biology Cleveland Clinic Lerner Research Institute and Taussig Cancer Center Cleveland OH 44195 USA

4. University of Montpellier CNRS UMR5048, INSERM U1054 Centre de Biologie Structurale 29 rue de Navacelles 34090 Montpellier France

5. Institute of Molecular and Cell Biology, A(✶)STAR 61 Biopolis Drive Singapore 138673 Singapore

6. Ecole Centrale Lille 59000 Lille France

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100153

Reference50 articles.

1. Mechanisms of Hippo pathway regulation

2. Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

3. Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Strategies that regulate Hippo signaling pathway for novel anticancer therapeutics;European Journal of Medicinal Chemistry;2024-10

2. Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription;EMBO Reports;2024-08-05

3. Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription;2023-08-16

4. Leveraging Hot Spots of TEAD–Coregulator Interactions in the Design of Direct Small Molecule Protein-Protein Interaction Disruptors Targeting Hippo Pathway Signaling;Pharmaceuticals;2023-04-13

5. Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP‐TEAD Protein‐Protein Interaction Inhibitors;ChemMedChem;2023-04-13