Affiliation:
1. Dipartimento di Scienze Chimiche Università degli Studi di Catania Viale A. Doria 6 95125 Catania Italy
2. UOC Bioterapie IRCCS Ospedale Policlinico San Martino Largo R. Benzi 10 16132 Genova Italy
3. Istituto di Cristallografia Consiglio Nazionale delle Ricerche Via Paolo Gaifami 18 95126 Catania Italy
Abstract
AbstractIn recent years, nanoparticles based on cyclodextrins have been widely investigated, mainly for drug delivery. In this work, we synthesized nanoparticles with a hyaluronic acid backbone (11 kDa and 45 kDa) functionalized with γ‐cyclodextrins. We tested sorafenib in the presence of the new hyaluronan‐cyclodextrin conjugates in A2780 (ovarian cancer), SK‐HeP‐1 (adenocarcinoma) and MDA‐MB‐453 (breast cancer) cell lines. We found that hyaluronan‐cyclodextrin conjugates improve the antiproliferative activity of sorafenib. Remarkably, the system based on the 11 kDa hyaluronan conjugate was the most effective and, in the MDA‐MB‐453 cell line, significantly reduced the IC50 value of sorafenib cells by about 75 %.
Funder
Ministero della Salute
Ministero dell'Università e della Ricerca