E7766, a Macrocycle‐Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan‐Genotypic Activity-Reference-Cited by-同舟云学术

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E7766, a Macrocycle‐Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan‐Genotypic Activity

Published:2021-02-25 Issue:11 Volume:16 Page:1741-1744
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Kim Dae‐Shik¹,Endo Atsushi¹,Fang Francis G.¹,Huang Kuan‐Chun²,Bao Xingfeng²,Choi Hyeong‐wook¹,Majumder Utpal¹,Shen Young Y.¹,Mathieu Steven¹,Zhu Xiaojie¹,Sanders Kristen¹,Noland Thomas¹,Hao Ming‐Hong¹,Chen Yu¹,Wang John Y.¹,Yasui So³,TenDyke Karen¹,Wu Jiayi²,Ingersoll Christy¹,Loiacono Kara A.¹,Hutz Janna E.¹,Sarwar Nadeem¹

Affiliation:

1. Eisai Inc. 35 Cambridgepark Drive Cambridge MA 02140 USA

2. H3 Biomedicine 300 Technology Square FL5 Cambridge MA 02139 USA

3. Analytical Research Laboratories Pharmaceutical Science & Technology, Eisai Co., Ltd. 5-1-3 Tokodai, Tsukuba-shi Ibaraki 300-2635 Japan

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100068

Reference29 articles.

1. STING is a direct innate immune sensor of cyclic di-GMP

2. Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

3.

4. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

5. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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