6‐Methyl‐7‐Aryl‐7‐Deazapurine Nucleosides as Anti‐ Trypanosoma cruzi Agents: Structure‐Activity Relationship and in vivo Efficacy-Reference-Cited by-同舟云学术

6‐Methyl‐7‐Aryl‐7‐Deazapurine Nucleosides as Anti‐ Trypanosoma cruzi Agents: Structure‐Activity Relationship and in vivo Efficacy

Published:2021-05-13 Issue:14 Volume:16 Page:2231-2253
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Lin Cai¹,Ferreira de Almeida Fiuza Ludmila²,Cardoso Santos Camila²,Ferreira Nunes Daniela³,Cruz Moreira Otacílio³^ORCID,Bouton Jakob¹,Karalic Izet¹,Maes Louis⁴,Caljon Guy⁴^ORCID,Hulpia Fabian¹⁵^ORCID,Nazaré C. Soeiro Maria²^ORCID,Van Calenbergh Serge¹^ORCID

Affiliation:

1. Laboratory for Medicinal Chemistry (Campus Heymans) Ghent University Ottergemsesteenweg 460 9000 Gent Belgium

2. Laboratório de Biologia Celular Instituto Oswaldo Cruz (FIOCRUZ) Fundação Oswaldo Cruz, Rio de Janeiro Avenida Brasil 4365, Manguinhos 21040-360 Rio de Janeiro Brazil

3. Plataforma de PCR em Tempo Real RPT09A-Laboratório de Biologia Molecular e Doenças Endêmicas Instituto Oswaldo Cruz (FIOCRUZ) Fundação Oswaldo Cruz, Rio de Janeiro Avenida Brasil 4365, Manguinhos 21040-360 Rio de Janeiro Brazil

4. Laboratory of Microbiology Parasitology and Hygiene University of Antwerp Universiteitsplein 1 2610 Wilrijk Belgium

5. Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse Belgium

Funder

Fonds Wetenschappelijk Onderzoek

Hercules Foundation

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100144