Development of Isatin‐Based Schiff Bases Targeting VEGFR‐2 Inhibition: Synthesis, Characterization, Antiproliferative Properties, and QSAR Studies

Author:

Seliem Israa A.12,Panda Siva S.2ORCID,Girgis Adel S.3ORCID,Tran Queen L.2,Said Mona F.4,Bekheit Mohamed S.3,Abdelnaser Anwar5,Nasr Soad6,Fayad Walid7,Soliman Ahmed A. F.7,Sakhuja Rajeev8,Ibrahim Tarek S.9,Abdel‐Samii Zakaria K. M.1,Al‐Mahmoudy Amany M. M.1

Affiliation:

1. Department of Pharmaceutical Organic Chemistry Faculty of Pharmacy Zagazig University 44519 Zagazig Egypt

2. Department of Chemistry and Physics Augusta University 30912 Augusta GA USA

3. Department of Pesticide Chemistry National Research Centre Dokki 12622 Giza Egypt

4. Department of Pharmaceutical Chemistry Faculty of Pharmacy Cairo University 11562 Cairo Egypt

5. Institute of Global Health and Human Ecology School of Sciences and Engineering The American University in Cairo (AUC) 11835 Cairo Egypt

6. Institute of Pharmacology of Natural Products & Clinical Pharmacology Ulm University 89081 Ulm Germany

7. Drug Bioassay-Cell Culture Laboratory Pharmacognosy Department National Research Centre Dokki 12622 Giza Egypt

8. Department of Chemistry Birla Institute of Technology and Science Pilani India

9. Department of Pharmaceutical Chemistry Faculty of Pharmacy King Abdulaziz University 21589 Jeddah Saudi Arabia

Funder

King Abdulaziz University

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference62 articles.

1. United Nations News “Cancer is a growing global threat and prevention is key UN study shows” https://news.un.org/en/story/2018/09/1019102(last accessed May 9 2022).

2. World Health Organization https://www.who.int/(last accessed May 9 2022).

3. Cancer statistics, 2022

4. TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities

5. Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

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