Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation-Reference-Cited by-同舟云学术

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Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation

Published:2022-07-07 Issue:16 Volume:17 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Wurm Konrad W.¹^ORCID,Bartz Frieda‐Marie¹,Schulig Lukas¹^ORCID,Bodtke Anja¹,Bednarski Patrick J.¹^ORCID,Link Andreas¹^ORCID

Affiliation:

1. Institute of Pharmacy University of Greifswald Friedrich-Ludwig-Jahn-Str. 17 17489 Greifswald Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202200262

Reference89 articles.

1.

2. Gating currents from neuronal KV7.4 Channels: General features and correlation with the ionic conductance

3. Heteromeric Kv7.2/7.3 Channels Differentially Regulate Action Potential Initiation and Conduction in Neocortical Myelinated Axons

4.

5. KCNQ potassium channels: physiology, pathophysiology, and pharmacology

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1. Identification of a new retigabine derivative with improved photostability for selective activation of neuronal Kv7 channels and antiseizure activity;Epilepsia;2024-08-14

2. Three-Step Synthesis of the Antiepileptic Drug Candidate Pynegabine;Molecules;2023-06-21

3. Structure‐Activity Relationships of Flupirtine Analogues for Liver Esterase‐Mediated Cleavage of the 4‐Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity;ChemMedChem;2023-05-31

4. Green electrosynthesis of drug metabolites;Toxicology Research;2023-03-07

5. A graphite furnace‐atomic absorption spectrometry‐based rubidium efflux assay for screening activators of the K_v7.2/3 channel;Archiv der Pharmazie;2023-02-07

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