Discovery of an Orally Active and Long‐Acting DPP‐IV Inhibitor through Property‐Based Optimization with an in Silico Biotransformation Prediction Tool-Reference-Cited by-同舟云学术

Discovery of an Orally Active and Long‐Acting DPP‐IV Inhibitor through Property‐Based Optimization with an in Silico Biotransformation Prediction Tool

Published:2020-07-02 Issue:16 Volume:15 Page:1608-1617
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Zeng Shaogao¹,Dou Wenyuan¹,Li Manna²,Zhou Yang³,Guo Jiehuang¹,Zhao Nan⁴,Huang Hong¹,Zhou Qiaoli¹,Hu Wenhui²,Ma Yanfang¹,Zhao Xin¹^ORCID,Xie Hui²^ORCID

Affiliation:

1. Guangdong Provincial Public Laboratory of Analysis and Testing TechnologyChina National Analytical CenterGuangdong Academy of Sciences 100 Xianlie Middle Avenue 510070 Guangzhou P. R. China

2. Department of PharmacyThe First Affiliated Hospital of Guangzhou Medical University 151 Yanjiang Road 510120 Guangzhou P. R. China

3. Division of Theoretical Chemistry and BiologySchool of BiotechnologyRoyal Institute of Technology (KTH)AlbaNova University Center Stockholm 100 44 Sweden

4. College of Biological ScienceUniversity of California One Shields Avenue CA95616 Davis USA

Funder

Natural Science Foundation of Guangdong Province

Bureau of Education of Guangzhou Municipality

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000175

Reference42 articles.

1. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

2. A Systematic Review of Adherence With Medications for Diabetes

3. The relation between intermittent dosing and adherence: Preliminary insights

5. Changes in medication adherence and unused drugs after switching from daily dipeptidyl peptidase-4 inhibitors to once-weekly trelagliptin in patients with type 2 diabetes

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