Discovery of an Orally Active and Long‐Acting DPP‐IV Inhibitor through Property‐Based Optimization with an in Silico Biotransformation Prediction Tool

Author:

Zeng Shaogao1,Dou Wenyuan1,Li Manna2,Zhou Yang3,Guo Jiehuang1,Zhao Nan4,Huang Hong1,Zhou Qiaoli1,Hu Wenhui2,Ma Yanfang1,Zhao Xin1ORCID,Xie Hui2ORCID

Affiliation:

1. Guangdong Provincial Public Laboratory of Analysis and Testing TechnologyChina National Analytical CenterGuangdong Academy of Sciences 100 Xianlie Middle Avenue 510070 Guangzhou P. R. China

2. Department of PharmacyThe First Affiliated Hospital of Guangzhou Medical University 151 Yanjiang Road 510120 Guangzhou P. R. China

3. Division of Theoretical Chemistry and BiologySchool of BiotechnologyRoyal Institute of Technology (KTH)AlbaNova University Center Stockholm 100 44 Sweden

4. College of Biological ScienceUniversity of California One Shields Avenue CA95616 Davis USA

Funder

Natural Science Foundation of Guangdong Province

Bureau of Education of Guangzhou Municipality

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

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