Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers-Reference-Cited by-同舟云学术

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Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers

Published:2021-02-02 Issue:7 Volume:16 Page:1184-1197
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Bergkemper Melanie¹,Schepmann Dirk¹,Wünsch Bernhard¹^ORCID

Affiliation:

1. Institut für Pharmazeutische und Medizinische Chemie Westfälische Wilhelms-Universität Münster Corrensstr. 48 48149 Münster Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000861

Reference40 articles.

1. Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

2. A proposal for the classification of sigma binding sites

3. Structural basis for σ1 receptor ligand recognition

4. Crystal structure of the human σ1 receptor

5. Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling

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