Affiliation:
1. State Key Laboratory of Anti-Infective Drug Discovery and Development School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 P. R. China
2. National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and Evaluation Sun Yat-sen University Guangzhou 510006 China
Abstract
AbstractMolecular optical probes play pivotal roles in in vivo imaging of biomarkers associated to kidney diseases. Relying on structural tunability and high fluorescence quantum yields, versatile optical probes have been constructed on cyanine or hemicyanine‐based scaffold in recent years. This review summaries the recent progress on the development of optical probes for imaging of kidney diseases, particularly through near‐infrared fluorescence, chemiluminescence and photoacoustic imaging modalities. The chemical design and sensing mechanisms are discussed along with applications in the detection of renal cell carcinoma and acute kidney injury. This progress provides insights and directions for the development of next generation kidney‐targeted probes and for pushing their further applications in preclinical and clinical research.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities