Affiliation:
1. Latvian Institute of Organic Synthesis Aizkraukles 21 1006 Riga Latvia
2. Institute of Technology of Organic Chemistry Faculty of Materials Science and Applied Chemistry Riga Technical University P. Valdena iela 3 1048 Riga Latvia
Abstract
AbstractThe synthetic approaches towards unique asparagusic acid and its analogues as well as its chemical use, the breadth of its biological properties and their relevant applications have been explored. The significance of the 1,2‐dithiolane ring tension in dithiol‐mediated uptake and its use for the intracellular transport of molecular cargoes is discussed alongside some of the challenges that arise from the fast thiolate‐disulfide interchange. The short overview with the indication of the available literature on natural 1,2‐dithiolanes synthesis and biological activities is also included. The general review structure is based on the time‐line perspective of the application of asparagusic acid moiety as well as its primitive derivatives (4‐amino‐1,2‐dithiolane‐4‐carboxylic acid and 4‐methyl‐1,2‐dithiolane‐4‐carboxilic acid) used in clinics/cosmetics, focusing on the recent research in this area and including international patents applications.
Subject
Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology
Cited by
2 articles.
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