Synthesis, Biological Evaluation, and Binding Mode of a New Class of Oncogenic K‐Ras4b Inhibitors-Reference-Cited by-同舟云学术

Synthesis, Biological Evaluation, and Binding Mode of a New Class of Oncogenic K‐Ras4b Inhibitors

Published:2022-09-23 Issue:22 Volume:17 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Jeuken Stephan¹,Shkura Oleksandr²,Röger Marc¹,Brickau Victoria³,Choidas Axel³,Degenhart Carsten³,Gülden Daniel¹,Klebl Bert³,Koch Uwe³,Stoll Raphael²,Scherkenbeck Jürgen¹^ORCID

Affiliation:

1. Faculty of Mathematics and Natural Sciences University of Wuppertal Gaussstrasse 20 42119 Wuppertal Germany

2. Faculty of Chemistry and Biochemistry Biomolecular Spectroscopy and RUBiospec | NMR University of Bochum Universitätsstrasse 150 44780 Bochum Germany

3. Lead Discovery Center GmbH Otto-Hahn-Strasse 15 44227 Dortmund Germany

Funder

European Regional Development Fund

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202200392

Reference61 articles.

1. “COSMIC – Catalogue of Somatic Mutations in Cancer.” can be found underhttps://cancer.sanger.ac.uk/cosmic.

2. RAS Proteins and Their Regulators in Human Disease

3. Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

4. Melanoma

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