Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity-Reference-Cited by-同舟云学术

Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity

Published:2021-03-25 Issue:11 Volume:16 Page:1799-1804
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Pflieger Marc¹^ORCID,Sönnichsen Melf²,Horstick‐Muche Nadine¹,Yang Jing²³,Schliehe‐Diecks Julian²,Schöler Andrea⁴,Borkhardt Arndt²,Hamacher Alexandra¹,Kassack Matthias U.¹,Hansen Finn K.⁵^ORCID,Bhatia Sanil²^ORCID,Kurz Thomas¹^ORCID

Affiliation:

1. Institut für Pharmazeutische und Medizinische Chemie Heinrich-Heine-Universität Düsseldorf Universitätsstr. 1 40225 Düsseldorf Germany

2. Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty Heinrich Heine University Düsseldorf Universitätsstr. 1 40225 Düsseldorf Germany

3. Department of Medicine Yangzhou Polytechnic College West Wenchang Road 458 Yangzhou 225009 P.R. China

4. Institute for Drug Discovery, Medical Faculty Leipzig University Brüderstraße 34 04103 Leipzig Germany

5. Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute University of Bonn An der Immenburg 4 53121 Bonn Germany

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202001011

Reference39 articles.

1. Inside HDAC with HDAC inhibitors

2. Histone deacetylases and cancer: causes and therapies

3. HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics

4. Post-translational Modifications Regulate Class IIa Histone Deacetylase (HDAC) Function in Health and Disease

5. HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases

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