Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation-Reference-Cited by-同舟云学术

Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation

Published:2021-02-12 Issue:7 Volume:16 Page:1077-1081
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Hamilton Joseph Z.¹^ORCID,Pires Thomas A.²,Mitchell Jamie A.¹,Cochran Julia H.¹,Emmerton Kim K.¹,Zaval Margo¹,Stone Ivan J.¹,Anderson Martha E.¹,Jin Steven¹,Waight Andrew B.³,Lyon Robert P.¹,Senter Peter D.¹,Jeffrey Scott C.¹,Burke Patrick J.¹

Affiliation:

1. Seagen Inc. 21823 30th Drive SE Bothell, WA 98021 USA

2. Department of Chemistry University of Illinois at Urbana-Champaign 505 South Mathews Ave. Urbana, IL 61801 USA

3. Protein Sciences Discovery Biologics Merck Research Laboratories 213 E Grand Ave. South San Francisco, CA 94080 USA

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000889

Reference31 articles.

1. Strategies and challenges for the next generation of antibody–drug conjugates

3. Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer

4. Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer

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