Challenges Based on Antiplasmodial and Antiviral Activities of 7‐Chloro‐4‐aminoquinoline Derivatives-Reference-Cited by-同舟云学术

Challenges Based on Antiplasmodial and Antiviral Activities of 7‐Chloro‐4‐aminoquinoline Derivatives

Published:2023-02-08 Issue:7 Volume:18 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Mizuta Satoshi¹^ORCID,Mosaddeque Farhana²,Tun Mya Myat Ngwe³,Teklemichael Awet Alem⁴,Taniguchi Mayumi⁴,Hosokawa Masashi⁵,Yamaguchi Tomoko¹,Makau Juliann⁶,Huy Nguyen Tien²⁷,Mizukami Shusaku⁴,Nishida Noriyuki⁸,Morita Kouichi³⁹,Hirayama Kenji²⁷

Affiliation:

1. Center for Bioinformatics and Molecular Medicine Nagasaki University 1-14 Bunkyo 852-8521 Nagasaki Japan

2. Department of Immunogenetics Institute of Tropical Medicine (NEKKEN) Nagasaki University 1-12-4 Sakamoto 852-8523 Nagasaki Japan

3. Department of Virology Institute of Tropical Medicine (NEKKEN) Nagasaki University 1-12-4 Sakamoto 852-8523 Nagasaki Japan

4. Department of Immune Regulation Shionogi Global Infectious Diseases Division Nagasaki University 1-12-4 Sakamoto 852-8523 Nagasaki Japan

5. School of Medicine Nagasaki University 1-12-4 Sakamoto 852-8523 Nagasaki Japan

6. Center for Virus Research Kenya Medical Research Institute 54840-00200 Nairobi Kenya

7. School of Tropical Medicine and Global Health Nagasaki University 1-12-4 Sakamoto 852-8102> Nagasaki Japan

8. Department of Molecular Microbiology and Immunology Nagasaki University 1-12-4 Sakamoto 852-8102 Nagasaki Japan

9. Dejima Infectious Disease Research Alliance Nagasaki University Nagasaki 852-8523 Japan

Abstract

AbstractWe report the structural functionalization of the terminal amino group of N1‐(7‐chloroquinolin‐4‐yl) butane‐1,4‐diamine, leading to a series of 7‐chloro‐4‐aminoquinoline derivatives, and their evaluation as potent anti‐malarial and anti‐viral agents. Some compounds exhibited promising anti‐malarial effects against the Plasmodium falciparum 3D7 (chloroquine‐sensitive) and Dd2 (chloroquine‐resistant) strains. In addition, these compounds were assayed in vitro against influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Compound 5 h, bearing an N‐mesityl thiourea group, displayed pronounced anti‐infectious effects against malaria, IAV, and SARS‐CoV‐2. These results provide new insights into drug discovery for the prevention or treatment of malaria and virus co‐infection.

Funder

Japan Agency for Medical Research and Development

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202200586

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