Developing Low Molecular Weight PET and SPECT Imaging Agents

Author:

Xue Lian1,Jie Caitlin V. M. L.2,Desrayaud Sandrine3,Auberson Yves P.4ORCID

Affiliation:

1. Monash Institute of Pharmaceutical Sciences Monash University 381 Royal Parade Parkville Victoria 3052 Australia

2. ETH Zürich Department of Chemistry and Applied Biosciences Center for Radiopharmaceutical Sciences Vladimir-Prelog Weg 1–5/10 8093 Zürich Switzerland

3. Novartis Biomedical Research In Vivo preclinical PK/ADME Novartis campus, WSJ-352/6/73.01 4056 Basel Switzerland

4. Novartis Biomedical Research Global Discovery Chemistry Novartis campus, WSJ-88.10.100 4056 Basel Switzerland

Abstract

AbstractImaging agents for positron emission tomography (PET) and single‐photon emission computerized tomography (SPECT) have shown their utility in many situations, answering clinical questions related to drug development and medical considerations. The discovery and development of imaging agents follow a well‐understood process, with variations related to available starting points and to the envisaged imaging application. This article describes the general development path leading from the expression of an imaging need and project initiation to a clinically usable imaging agent. The definition of the project rationale, the design and optimization of early leads, and the assessment of the imaging potential of an imaging agent candidate are followed by preclinical and clinical development activities that differ from those required for therapeutic agents. These include radiolabeling with a positron emitter and first‐in‐human clinical studies, to rapidly evaluate the ability of a new imaging agent to address the questions it was designed to answer.

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3