Affiliation:
1. School of Chemistry Trinity Biomedical Sciences Institute 152-160 Pearse Street Trinity College Dublin Ireland
2. School of Biochemistry & Immunology Trinity Biomedical Sciences Institute 152-160 Pearse Street Trinity College Dublin Ireland
Abstract
AbstractA library of queuine analogues targeting the modification of tRNA isoacceptors for Asp, Asn, His and Tyr catalysed by queuine tRNA ribosyltransferase (QTRT, also known as TGT) was evaluated in the treatment of a chronic multiple sclerosis model: murine experimental autoimmune encephalomyelitis. Several active 7‐deazaguanines emerged, together with a structure–activity relationship involving the necessity for a flexible alkyl chain of fixed length.
Subject
Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology