Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment-Reference-Cited by-同舟云学术

Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment

Published:2020-07-07 Issue:16 Volume:15 Page:1552-1561
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Maiorana Santina¹,Ettari Roberta¹,Previti Santo¹,Amendola Giorgio²,Wagner Annika³⁴,Cosconati Sandro²,Hellmich Ute A.³⁴,Schirmeister Tanja⁵,Zappalà Maria¹^ORCID

Affiliation:

1. Department of Chemical, Biological, Pharmaceutical and Environmental SciencesUniversity of Messina Viale Annunziata 98168 Messina Italy

2. DiSTABiFUniversity of Campania Luigi Vanvitelli Via Vivaldi 43 81100 Caserta Italy

3. Department Centre for Biomolecular Magnetic Resonance (BMRZ) Max von Laue Str. 9 60438 Frankfurt Germany

4. Department of Chemistry Section BiochemistryUniversity of Mainz Johann-Joachim-Becherweg 30 55128 Mainz Germany

5. Institute of Pharmaceutical and Biomedical SciencesUniversity of Mainz Staudingerweg 5 55128 Mainz Germany

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000360

Reference52 articles.

1. Human African Trypanosomiasis World Health Organization: Geneva 2019; https://www.who.int/trypanosomiasis_african/en/ (May 2 2020).

2. Human African trypanosomiasis

3. Stage Progression and Neurological Symptoms in Trypanosoma brucei rhodesiense Sleeping Sickness: Role of the CNS Inflammatory Response

4. A multicentre, randomised, non-inferiority clinical trial comparing a nifurtimox-eflornithine combination to standard eflornithine monotherapy for late stage Trypanosoma brucei gambiense human African trypanosomiasis in Uganda

5. New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice

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