An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram‐negative Pathogens and Reduced ex vivo Cochleotoxicity-Reference-Cited by-同舟云学术

An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram‐negative Pathogens and Reduced ex vivo Cochleotoxicity

Published:2020-10-23 Issue:2 Volume:16 Page:335-339
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Sonousi Amr¹²,Quirke Jonathan C. K.³,Waduge Prabuddha²,Janusic Tanja⁴,Gysin Marina⁴,Haldimann Klara⁴,Xu Shan⁵,Hobbie Sven N.⁴,Sha Su‐Hua⁵,Schacht Jochen⁶,Chow Christine S.²,Vasella Andrea⁷,Böttger Erik C.⁴,Crich David³²^ORCID

Affiliation:

1. Department of Pharmaceutical Organic Chemistry Faculty of Pharmacy Cairo University Cairo 11562 Egypt

2. Department of Chemistry Wayne State University 5101 Cass Avenue Detroit MI 48202 USA

3. Department of Pharmacy and Biomedical Sciences and Department of Chemistry and Complex Carbohydrate Research Center University of Georgia 250 West Green Street Athens GA 30602 USA

4. Institute of Medical Microbiology University of Zurich Gloriastrasse 28 8006 Zürich Switzerland

5. Department of Pathology and Laboratory Medicine Medical University of South Carolina Walton Research Building, Room 403-E 39 Sabin Street Charleston SC 29425 USA

6. Kresge Hearing Research Institute Department of Otolaryngology University of Michigan 1150 West Medical Center Drive Ann Arbor MI 48109 USA

7. Organic Chemistry Laboratory ETH Zürich Vladimir-Prelog-Weg 1–5/10 8093 Zürich Switzerland

Funder

National Institutes of Health

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000726

Reference49 articles.

2. Aminoglycosides: Time for the Resurrection of a Neglected Class of Antibacterials?

3. Destination of aminoglycoside antibiotics in the ‘post-antibiotic era’

4. Apramycin, a unique aminocyclitol antibiotic

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