Direct, Late‐Stage Mono‐ N ‐arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine‐Resistant Parasites-Reference-Cited by-同舟云学术

Direct, Late‐Stage Mono‐ N ‐arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine‐Resistant Parasites

Published:2021-09-02 Issue:22 Volume:16 Page:3396-3401
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Robertson Jack¹,Ungogo Marzuq A.²,Aldfer Mustafa M.²,Lemgruber Leandro³,McWhinnie Fergus S.¹,Bode Bela E.⁴,Jones Katherine L.⁵,Watson Allan J. B.⁴,Koning Harry P.²,Burley Glenn A.¹

Affiliation:

1. Department of Pure and Applied Chemistry University of Strathclyde 295 Cathedral Street Glasgow G1 1XL UK

2. Institute of Infection, Immunity, and Inflammation College of Medical, Veterinary, and Life Sciences University of Glasgow Glasgow G12 8TA UK

3. Glasgow Imaging Facility Institute of Infection, Immunity, and Inflammation College of Medical Veterinary and Life Sciences University of Glasgow Glasgow G12 8TA UK

4. EaStCHEM School of Chemistry University of St Andrews North Haugh St Andrews Fife KY16 9ST UK

5. GlaxoSmithKline Medicines Research Centre Gunnels Wood Road Stevenage Hertfordshire SG1 2NY UK

Funder

GlaxoSmithKline

Engineering and Physical Sciences Research Council

Petroleum Technology Development Fund

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100509

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