Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes

Author:

Malpetti Maura1,Jones P. Simon1,Tsvetanov Kamen A.1,Rittman Timothy1,Swieten John C.2,Borroni Barbara3,Sanchez‐Valle Raquel4,Moreno Fermin56,Laforce Robert7,Graff Caroline89,Synofzik Matthis1011,Galimberti Daniela1213,Masellis Mario14,Tartaglia Maria Carmela15,Finger Elizabeth16,Vandenberghe Rik171819,Mendonça Alexandre20,Tagliavini Fabrizio21,Santana Isabel2223,Ducharme Simon2425,Butler Chris R.26,Gerhard Alexander2728,Levin Johannes293031,Danek Adrian29,Otto Markus32,Frisoni Giovanni B.33,Ghidoni Roberta34,Sorbi Sandro3536,Heller Carolin37,Todd Emily G.37,Bocchetta Martina37,Cash David M.37,Convery Rhian S.37,Peakman Georgia37,Moore Katrina M.37,Rohrer Jonathan D.37,Kievit Rogier A.3839,Rowe James B.138,(GENFI) Genetic FTD Initiative

Affiliation:

1. Department of Clinical Neurosciences Cambridge University Hospitals NHS Trust University of Cambridge Cambridge UK

2. Department of Neurology Erasmus Medical Centre Rotterdam Netherlands

3. Department of Clinical and Experimental Sciences Centre for Neurodegenerative Disorders University of Brescia Brescia Italy

4. Alzheimer's disease and Other Cognitive Disorders Unit Neurology Service Hospital Clínic Institut d'Investigacións Biomèdiques August Pi I Sunyer University of Barcelona Barcelona Spain

5. Department of Neurology Cognitive Disorders Unit Donostia Universitary Hospital San Sebastian Spain

6. Neuroscience Area Biodonostia Health Research Institute San Sebastian Gipuzkoa Spain

7. Clinique Interdisciplinaire de Mémoire Département des Sciences Neurologiques CHU de Québec Faculté de Médecine Université Laval Québec Canada

8. Department of Neurobiology Care Sciences and Society Center for Alzheimer Research Division of Neurogeriatrics Bioclinicum Karolinska Institutet Solna Sweden

9. Unit for Hereditary Dementias Theme Aging Karolinska University Hospital Solna Sweden

10. Department of Neurodegenerative Diseases Hertie‐Institute for Clinical Brain Research and Center of Neurology University of Tübingen Tübingen Germany

11. Center for Neurodegenerative Diseases (DZNE) Tübingen Germany

12. Fondazione Ca’ Granda IRCCS Ospedale Policlinico Milan Italy

13. Centro Dino Ferrari University of Milan Milan Italy

14. Sunnybrook Health Sciences Centre Sunnybrook Research Institute University of Toronto Toronto Canada

15. Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada

16. Department of Clinical Neurological Sciences University of Western Ontario London Ontario Canada

17. Department of Neurosciences Laboratory for Cognitive Neurology KU Leuven Leuven Belgium

18. Neurology Service University Hospitals Leuven Leuven Belgium

19. KU Leuven Leuven Brain Institute Leuven Belgium

20. Faculty of Medicine University of Lisbon Lisbon Portugal

21. Fondazione IRCCS Istituto Neurologico Carlo Besta Milano Italy

22. University Hospital of Coimbra (HUC) Neurology Service Faculty of Medicine University of Coimbra Coimbra Portugal

23. Center for Neuroscience and Cell Biology Faculty of Medicine University of Coimbra Coimbra Portugal

24. Department of Psychiatry McGill University Health Centre McGill University Montreal Québec Canada

25. McConnell Brain Imaging Centre Montreal Neurological Institute McGill University Montreal Québec Canada

26. Nuffield Department of Clinical Neurosciences Medical Sciences Division University of Oxford Oxford UK

27. Division of Neuroscience and Experimental Psychology Wolfson Molecular Imaging Centre University of Manchester Manchester UK

28. Departments of Geriatric Medicine and Nuclear Medicine University of Duisburg‐ Essen Duisburg Germany

29. Department of Neurology Ludwig‐Maximilians Universität München Munich Germany

30. German Center for Neurodegenerative Diseases (DZNE) Munich Germany

31. Munich Cluster of Systems Neurology (SyNergy) Munich Germany

32. Department of Neurology University of Ulm Ulm Germany

33. IRCCS Centro San Giovanni di Dio Fatebenefratelli Brescia Italy

34. Molecular Markers Laboratory IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy

35. Department of Neuroscience Psychology Drug Research and Child Health University of Florence Florence Italy

36. IRCCS Fondazione Don Carlo Gnocchi Florence Italy

37. Department of Neurodegenerative Disease Dementia Research Centre UCL Queen Square Institute of Neurology University College London London UK

38. MRC Cognition and Brain Sciences Unit University of Cambridge Cambridge UK

39. Cognitive Neuroscience Department Donders Institute for Brain Cognition and Behavior Radboud University Medical Center Nijmegen Netherlands

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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