Affiliation:
1. Guangxi Key Laboratory of Regenerative Medicine, Orthopaedics Trauma and Hand Surgery The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China
2. Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co‐constructed by the Province and Ministry Guangxi Medical University Nanning Guangxi China
3. Pharmaceutical College Guangxi Medical University Nanning Guangxi China
4. School of Clinical Medicine Jiangxi University of Traditional Chinese Medicine Nanchang Jiangxi China
Abstract
AbstractPost‐menopausal osteoporosis (PMOP) is a common metabolic bone malady characterized by bone mass loss and bone microarchitectural deterioration; however, there is currently no effective drug for its management. According to our previous study, oroxylin A (OA) could effectively protect ovariectomized (OVX)‐osteoporotic mice from bone loss; however, its therapeutic targets are still unclear. From a metabolomic perspective, we studied serum metabolic profiles to discover potential biomarkers and OVX‐related metabolic networks, which could assist us to comprehend the impact of OA on OVX. Five metabolites were identified as biomarkers associated with 10 related metabolic pathways, including phenylalanine, tyrosine and tryptophan biosynthesis, and phenylalanine, tryptophan and glycerophospholipid metabolism. After OA treatment, the expression of multiple biomarkers changed, with lysophosphatidylcholine (18:2) being a major significantly regulated biomarker. Our study demonstrated that OA's effects on OVX are probably related to the regulation of phenylalanine, tyrosine and tryptophan biosynthesis. Our findings explain the role of OA against PMOP in terms of metabolism and pharmacology and provide a pharmacological foundation for OA treatment of PMOP.
Funder
Natural Science Foundation of Guangxi Province
Specific Research Project of Guangxi for Research Bases and Talents
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry
Cited by
1 articles.
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