Affiliation:
1. Department of Chemistry and Biochemistry University of California, Santa Barbara Santa Barbara CA, 93106 USA
Abstract
AbstractBy combining tandem asymmetric gold catalysis and subsequent stereoconvergent hydrolysis of enol ester in a one‐pot process, hydroxylated propargylic esters are converted into chiral β‐oxygenated ketones with mostly good enantiomeric ratios and in largely good to excellent yields. The product chiral center is formed via stereoselective cyclization of a hydroxylated allenyl ester intermediate, which is enabled by asymmetric gold‐ligand cooperation.
Funder
National Institute of General Medical Sciences
National Science Foundation