Gold‐Catalyzed Asymmetric Transformation of Hydroxylated Propargylic Esters

Abstract

AbstractBy combining tandem asymmetric gold catalysis and subsequent stereoconvergent hydrolysis of enol ester in a one‐pot process, hydroxylated propargylic esters are converted into chiral β‐oxygenated ketones with mostly good enantiomeric ratios and in largely good to excellent yields. The product chiral center is formed via stereoselective cyclization of a hydroxylated allenyl ester intermediate, which is enabled by asymmetric gold‐ligand cooperation.