1D and 2D Coordination Polymers of Calcium with Nonsteroidal Anti‐Inflammatory Drugs: Synthesis, Crystal Structures, Hirshfeld Surfaces, Antimicrobial and Antioxidant Activities

Author:

Gacki Michał1ORCID,Kafarska Karolina1ORCID,Korona‐Głowniak Izabela2,Schab Patrycja1ORCID,Wojciechowski Jakub3ORCID,Gierczak Natalia1ORCID,Wolf Wojciech M.1ORCID

Affiliation:

1. Institute of General and Ecological Chemistry Faculty of Chemistry Łódź University of Technology Żeromskiego 116 90-924 Łódź Poland

2. Department of Pharmaceutical Microbiology Medial University of Lublin Chodźki 1 20-093 Lublin Poland

3. Rigaku Europe SE Hugenottenallee 167 63263 Neu-Isenburg Germany

Abstract

AbstractFour alkaline earth metal complexes of ketoprofen (Hket) and indomethacin (Hind) were synthesized and characterized: [Ca(ket)2(H2O)2]n (1), [Mg(ket)2(H2O)2] (2), [Ca(ind)2(EtOH)2]n (3), and [Mg(ind)2(EtOH)2] (4). All compounds were studied by elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). Crystal structures of 1 and 3 were determined by single crystal X‐ray diffraction technique T=100 K. The structure of 1 is dominated by a one‐dimensional coordination polymer, while 3 is formed by a two‐dimensional layer stabilized by the calcium zig‐zag chains and π⋅⋅⋅π stacking interactions. Crystal packing arrangements were characterized by fingerprint plots (FPs) that were derived from the Hirshfeld surfaces (HSs). The antioxidant and antimicrobial activities of complexes were evaluated against Gram‐positive and Gram‐negative bacteria as well as yeasts.

Funder

Wydział Chemiczny, Politechnika Łódzka

Publisher

Wiley

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