Affiliation:
1. Laboratório de Síntese Orgânica Instituto de Pesquisas de Produtos Naturais Universidade Federal do Rio de Janeiro 21941-599 Rio de Janeiro Brasil
2. Laboratório de Biocatálise e Síntese Orgânica Instituto de Química Universidade Federal do Rio de Janeiro 21941-902 Rio de Janeiro Brasil
3. Divisão de Metrologia Química e Térmica Instituto Nacional de Metrologia Qualidade e Tecnologia 25250-020 Rio de Janeiro Brasil
Abstract
AbstractCertified reference materials (CRM) of amphetamine derivatives were produced through a simple, rapid and efficient synthesis in both batch and continuous‐flow conditions, accompanied by the development of a comprehensive certification protocol for this class of substances. Our chemistry enabled the synthesis of MDA, MDMA, PMA and PMMA in two steps from safrole and estragole with overall yields of 38–61 % in 48 hours under batch conditions and 61–65 % in 65 minutes under continuous‐flow conditions, followed by the development of a certification protocol for these materials through identity checking, homogeneity, stability, and characterization studies. Furthermore, as result of this work, a very pure CRM of MDA.HCl with 99.1±1.4 g/100 g of certified characterization value was produced. Considering the importance of supplying amphetamine calibrants for public security efforts in Forensic Chemistry, the potential therapeutical applications, and responding to the rising demand for the synthesis of CRM, this work presents a pioneering approach for the production of amphetamine and related compounds.
Reference34 articles.
1. Retrospective analysis of forensic toxicology data from 2021 to identify patterns of various forensic cases
2. ISO Guide 35 (2017) Reference materials - Guidance for characterization and assessment of homogeneity and stability. ISO Geneva.
3.
4. Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine
5. UNODC World Drug Report 2022(United Nations publication 2022;