Affiliation:
1. Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 China
2. University of Chinese Academy of Sciences Beijing 100049 China
3. Fuzhou University College of Chemistry Fuzhou 350108 China
4. Institute of Smart Biomedical Materials School of Materials Science and Engineering Zhejiang Sci-Tech University Hangzhou 310018 China
Abstract
AbstractPhoto‐responsive synergetic therapeutics achieved significant attraction in cancer theranostic due to the versatile characteristics of nanomaterials. There have been substantial efforts in developing the simplest nano‐design with exceptional synergistic properties and multifunctionalities. In this work, biocompatible Ti2C MXene nano bipyramids (MNBPs) were synthesized by hydrothermal method with dual functionalities of photothermal and photodynamic therapies. The MNBPs shape was obtained from two‐dimensional (2D) Ti2C nanosheets by controlling the temperature of the reaction mixture. The structure of these Ti2C MNBPs was characterized by a high‐resolution transmission electron microscope, scanning electron microscope, atomic force microscope, X‐ray photoelectron spectroscopy, and X‐ray diffraction. The Ti2C NBPs have shown exceptional photothermal properties with increased temperature to 72.3 °C under 808 nm laser irradiation. The designed nano bipyramids demonstrated excellent cellular uptake and biocompatibility. The Ti2C NBP has established a remarkable photothermal therapy (PTT) effect against 4T1 breast cancer cells. Moreover, Ti2C NBPs showed a profound response to UV light (6 mW/cm2) and produced reactive oxygen species, making them useful for photodynamic therapy (PDT). These in‐vitro studies pave a new path to tune the properties of photo‐responsive MXene nanosheets, indicating a potential use in biomedical applications.
Funder
National Natural Science Foundation of China
Youth Innovation Promotion Association of the Chinese Academy of Sciences