AParkinson's disease gene, DJ-1, repairs brain injury through Sox9 stabilization and astrogliosis

Author:

Choi Dong-Joo123,Eun Jin-Hwa123,Kim Byung Gon1345,Jou Ilo123,Park Sang Myun123,Joe Eun-Hye1234ORCID

Affiliation:

1. Neuroscience Graduate Program, Department of Biomedical Sciences; Ajou University School of Medicine, Worldcup-ro 164; Suwon Kyunggi-do 16499 Korea

2. Department of Pharmacology; Ajou University School of Medicine, Worldcup-ro 164; Suwon Kyunggi-do 16499 Korea

3. Chronic Inflammatory Disease Research Center; Ajou University School of Medicine, Worldcup-ro 164; Suwon Kyunggi-do 16499 Korea

4. Department of Brain Science; Ajou University School of Medicine, Worldcup-ro 164; Suwon Kyunggi-do 16499 Korea

5. Department of Neurology; Ajou University School of Medicine, Worldcup-ro 164; Suwon Kyunggi-do 16499 Korea

Funder

National Research Foundation of Korea

Korea Science and Engineering Foundation

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Neurology

Reference69 articles.

1. The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site;Akiyama;Matrix Biology,2005

2. Astrocyte scar formation aids central nervous system axon regeneration;Anderson;Nature,2016

3. GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo;Arenas;Neuron,1995

4. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies;Baba;The American Journal of Pathology,1998

5. Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: A real-time PCR study;Backman;Molecular and Cellular Endocrinology,2006

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