High rates of anal Merkel Cell Polyomavirus and HPV co‐infection among people living with HIV-Reference-Cited by-同舟云学术

High rates of anal Merkel Cell Polyomavirus and HPV co‐infection among people living with HIV

Published:2024-08 Issue:8 Volume:96 Page:
ISSN:0146-6615
Container-title:Journal of Medical Virology
language:en
Short-container-title:Journal of Medical Virology

Author:

Passerini Sara¹,Fracella Matteo²,Benvenuto Domenico³^ORCID,Bugani Ginevra¹,D'Auria Alessandra²,Coratti Eleonora²,Babini Giulia¹,Moens Ugo⁴,Cavallari Eugenio Nelson¹,Torti Carlo³⁵,Antonelli Guido²^ORCID,Ciccozzi Massimo⁶^ORCID,Pierangeli Alessandra²^ORCID,d'Ettorre Gabriella¹,Scagnolari Carolina²^ORCID,Pietropaolo Valeria¹

Affiliation:

1. Department of Public Health and Infectious Diseases Sapienza University of Rome Rome Italy

2. Department of Molecular Medicine, Laboratory of Virology Sapienza University of Rome Rome Italy

3. Dipartimento di Sicurezza e Bioetica, Sezione di Malattie Infettive Università Cattolica del Sacro Cuore Rome Italy

4. Department of Medical Biology, Faculty of Health Sciences University of Tromsø‐The Arctic University of Norway Tromsø Norway

5. Dipartimento di Scienze di Laboratorio e Infettivologiche Fondazione Policlinico Universitario “A. Gemelli” IRCCS Rome Italy

6. Unit of Medical Statistics and Molecular Epidemiology University Campus Bio‐Medico of Rome Rome Italy

Abstract

AbstractKnowledge of Human Polyomavirus (HPyV) infection in the anal area and its association with sexually transmitted infections such as Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) remains limited. Therefore, anal specimens from 150 individuals of both sexes were analyzed for screening purposes. HPV DNA was found in 50.7% of cases, with a predominance of high‐risk (HR) genotypes. HPyV DNA was found in 39.3% of samples, with Merkel Cell Polyomavirus (MCPyV) being the most common, with a higher viral load than JCPyV and BKPyV. In addition, MCPyV viral load increased in people living with HIV (PLWH) with HPV infection (p < 0.0001).

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.29883

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