A functional substitution in the L‐aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway

Author:

Khoury Samar1ORCID,Piltonen Marjo H.1,Ton Anh‐Tien2,Cole Tiffany3,Samoshkin Alexander14,Smith Shad B.5,Belfer Inna6,Slade Gary D.7,Fillingim Roger B.8,Greenspan Joel D.9,Ohrbach Richard10,Maixner William5,Neely G. Gregory3,Serohijos Adrian W. R.2,Diatchenko Luda1

Affiliation:

1. Alan Edwards Centre for Research on PainMcGill University Montreal Quebec Canada

2. Department of Biochemistry, Robert Cedergren Centre on Bioinformatics and GenomicsUniversity of Montreal Montreal Quebec Canada

3. Dr John and Anne Chong Laboratory for Functional Genomics, Charles Perkins Centre and School of Life and Environmental SciencesUniversity of Sydney Sydney New South Wales Australia

4. School of Clinical MedicineUniversity of Cambridge Cambridge United Kingdom

5. Department of Anesthesia, Center for Translational Pain MedicineDuke University Medical Center Durham NC

6. National Center for Complementary and Integrative HealthNational Institutes of Health Bethesda MD

7. Department of Dental Ecology, School of DentistryUniversity of North Carolina Chapel Hill Chapel Hill NC

8. University of Florida Pain Research and Intervention Center of Excellence, College of DentistryUniversity of Florida Gainesville FL

9. Department of Neural and Pain Sciences, Brotman Facial Pain ClinicSchool of Dentistry, University of Maryland Baltimore MD

10. Department of Oral Diagnostic ServicesUniversity at Buffalo Buffalo NY

Funder

Canada Excellence Research Chairs, Government of Canada

Canadian Institutes of Health Research

National Institute of Dental and Craniofacial Research

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Reference52 articles.

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2. Somatic awareness and symptom attribution in ischemic stroke patients;Reynolds E;J Neurosci Nurs,2014

3. Explaining medically unexplained symptoms-models and mechanisms

4. Medically unexplained physical symptoms, somatization disorder and abridged somatization: studies with the Diagnostic Interview Schedule;Escobar JI;Psychiatr Dev,1989

5. Somatization: a spectrum of severity

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