Course of Impulse Control Disorder Symptoms in Parkinson's Disease: Deep Brain Stimulation Versus Medications

Author:

Hernandez‐Con Pilar1,Lin Iris2,Mamikonyan Eugenia3,Deeb Wissam4,Feldman Robert5,Althouse Andrew5,Barmore Ryan6,Eisinger Robert S.78,Spindler Meredith7,Okun Michael S.8,Weintraub Daniel37ORCID,Chahine Lana M.9ORCID

Affiliation:

1. Department of Pharmaceutical Outcomes and Policy University of Florida Gainesville Florida USA

2. Department of Neurology University of Cincinnati Cincinnati Ohio USA

3. Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA

4. Department of Neurology University of Massachusetts Amherst Massachusetts USA

5. Center for Research on Health Care Data Center University of Pittsburgh Pittsburgh Pennsylvania USA

6. Department of Neurology Banner Health Phoenix Arizona USA

7. Department of Neurology University of Pennsylvania Philadelphia Pennsylvania USA

8. Department of Neurology Norman Fixel Institute for Neurological Diseases, University of Florida Gainesville Florida USA

9. Department of Neurology University of Pittsburgh Pittsburgh Pennsylvania USA

Abstract

AbstractBackgroundThe effect of surgery on impulse control disorders (ICDs) remains unclear in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS).ObjectiveTo examine changes in ICD symptoms in PD patients undergoing DBS compared to a medication‐only control group.MethodsThe study was a 2‐center, 12‐month, prospective, observational investigation of PD patients undergoing DBS and a control group matched on age, sex, dopamine agonist use, and baseline presence of ICDs. Questionnaire for Impulsive‐Compulsive Disorders in Parkinson's Disease‐Rating Scale (QUIP‐RS) and total levodopa equivalent daily dose (LEDD) were collected at baseline, 3, 6, and 12 months. Linear mixed‐effects models assessed changes in mean QUIP‐RS score (sum of buying, eating, gambling, and hypersexuality items).ResultsThe cohort included 54 participants (DBS = 26, controls = 28), mean (SD) age 64.3 (8.1) and PD duration 8.0 (5.2) years. Mean baseline QUIP‐RS was higher in the DBS group at baseline (8.6 (10.7) vs. 5.3 (6.9), P = 0.18). However, scores at 12 months follow‐up were nearly identical (6.6 (7.3) vs. 6.0 (6.9) P = 0.79). Predictors of change in QUIP‐RS score were baseline QUIP‐RS score (β = 0.483, P < 0.001) and time‐varying LEDD (β = 0.003, P = 0.02). Eight patients (four in each group) developed de novo ICD symptoms during follow‐up, although none met diagnostic criteria for an impulse control disorder.ConclusionsICD symptoms (including de novo symptoms) at 12 months follow‐up were similar between PD patients undergoing DBS and patients treated with pharmacological therapy only. Monitoring for emergence of ICD symptoms is important in both surgically‐ and medication‐only‐treated PD patients.

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3