Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia-Reference-Cited by-同舟云学术

Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia

Published:2023-05-05 Issue:6 Volume:10 Page:980-986
ISSN:2330-1619
Container-title:Movement Disorders Clinical Practice
language:en
Short-container-title:Movement Disord Clin Pract

Author:

Gonzalez Maria Camila¹²³^ORCID,Tovar‐Rios Diego Alejandro³⁴,Alves Guido²⁵⁶,Dalen Ingvild⁶,Williams‐Gray Caroline H.⁷^ORCID,Camacho Marta⁷^ORCID,Forsgren Lars⁸,Bäckström David⁸,Lawson Rachael A.⁹,Macleod Angus D.¹⁰^ORCID,Counsell Carl E.¹¹,Paquet Claire¹²,DeLena Carlo¹³,D'Antonio Fabrizia¹³,Pilotto Andrea¹⁴^ORCID,Padovani Alessandro¹⁴,Blanc Frédéric¹⁵,Falup‐Pecurariu Cristian¹⁶,Lewis Simon J.G.¹⁷^ORCID,Rejdak Konrad¹⁸,Papuc Ewa¹⁸,Hort Jakub¹⁹,Nedelska Zuzana¹⁹,O'Brien John²⁰,Bonanni Laura²¹,Marquié Marta²²,Boada Mercè²²,Pytel Vanesa²²,Abdelnour Carla²³^ORCID,Alcolea Daniel²⁴,Beyer Katrin²⁵,Tysnes Ole‐Bjørn²⁶,Aarsland Dag³²⁷,Maple‐Grødem Jodi²⁵^ORCID

Affiliation:

1. Department of Quality and Health Technology, Faculty of Health Sciences University of Stavanger Stavanger Norway

2. The Norwegian Centre for Movement Disorders Stavanger University Hospital Stavanger Norway

3. Centre for Age‐Related Medicine Stavanger University Hospital Stavanger Norway

4. Grupos de investigación INFERIR and PRECEC, Section of Biostatistics Universidad del Valle Santiago de Cali Colombia

5. Department of Chemistry, Bioscience and Environmental Engineering University of Stavanger Stavanger Norway

6. Department of Neurology Stavanger University Hospital Stavanger Norway

7. Department of Clinical Neurosciences University of Cambridge Cambridge England

8. Department of Clinical Science, Neurosciences Umeå University Umeå Sweden

9. Translational and Clinical Research Institute Newcastle University Tyne UK

10. Institute of Applied Health Sciences University of Aberdeen Aberdeen UK

11. Institute of Applied Health Sciences University of Aberdeen, Polwarth Building Aberdeen UK

12. Université de Paris, Cognitive Neurology Center, APHP, Lariboisière Fernand‐Widal Hospital Paris France

13. Department of Human Neurosciences Sapienza University of Rome Rome Italy

14. Neurology Unit, Department of Clinical and Experimental Sciences University of Brescia Brescia Italy

15. Memory Resource and Research Centre (CM2R), Geriatrics Day Hospital, Geriatrics Department University Hospital of Strasbourg Strasbourg Cedex France

16. Department of Neurology, County Clinic Hospital, Faculty of Medicine Transilvania University Brasov Romania

17. The University of Sydney Camperdown Australia

18. Department of Neurology Medical University of Lublin Lublin Poland

19. Memory Clinic, Department of Neurology Charles University, 2nd Faculty of Medicine and Motol University Hospital Prague Czech Republic

20. Department of Psychiatry University of Cambridge School of Clinical Medicine Cambridge UK

21. Department of Medicine and Aging Sciences University Gd'Annunzio of Chieti‐Pescara Chieti Italy

22. Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya Barcelona Spain

23. Department of Neurology and Neurological Sciences Stanford University School of Medicine Stanford California USA

24. Sant Pau Memory Unit, Department of Neurology, IIB Sant Pau—Hospital de Sant Pau Universitat Autònoma de Barcelona Barcelona Spain

25. Department Neuroscience Research Institute Germans Trias i Pujol Badalona Spain

26. Department of Neurology Haukeland University Hospital Bergen Norway

27. Department of Old Age Psychiatry Institute of Psychiatry, Psychology, and Neuroscience, King's College London London UK

Abstract

ABSTRACTBackgroundThere is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD).ObjectivesTo compare the rate of cognitive and motor decline in patients with DLB and PDD from the E‐DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts.MethodsThe annual change in MMSE and MDS‐UPDRS part III was estimated using linear mixed regression models in patients with at least one follow‐up (DLB n = 837 and PDD n = 157).ResultsWhen adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS‐UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]).ConclusionsDLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.

Funder

Academy of Medical Sciences

CPT

Generalitat de Catalunya

Helse Vest

Hjärnfonden

Instituto de Salud Carlos III

Knut och Alice Wallenbergs Stiftelse

Medicinska Forskningsrådet

National Institute for Health Research

Parkinson's UK

Umeå Universitet