Night‐Time Apomorphine Infusion: Who Are the Best Candidates?-Reference-Cited by-同舟云学术

Night‐Time Apomorphine Infusion: Who Are the Best Candidates?

Published:2023-06-13 Issue:8 Volume:10 Page:1192-1197
ISSN:2330-1619
Container-title:Movement Disorders Clinical Practice
language:en
Short-container-title:Movement Disord Clin Pract

Author:

Cochen De Cock Valérie¹²^ORCID,Dodet Pauline³,Leu‐Semenescu Smaranda³,Aerts Cécile¹²,Abril Beatriz⁴,Castelnovo Giovanni⁵,Landragin Nicolas⁶,Drapier Sophie⁷,Olivet Hélène⁸,Corbillé Anne‐Gaëlle⁹,Leclair‐Visonneau Laurène¹⁰,Anheim Mathieu¹¹¹²,Vidailhet Marie¹³¹⁴,Arnulf Isabelle³¹⁴^ORCID,Doulazmi Mohamed¹⁵,Roze Emmanuel¹³¹⁴,

Affiliation:

1. Sleep and Neurology Department Beau Soleil Clinic Montpellier France

2. EuroMov Digital Health in Motion Univ Montpellier, IMT Mines Alès Montpellier France

3. Sleep Disorders Unit Pitié‐Salpêtrière University Hospital Paris France

4. Sleep Department University Hospital of Nîmes Nîmes France

5. Department of Neurology University Hospital of Nîmes Nîmes France

6. Clinique du Millénaire Montpellier France

7. Department of Neurology Pontchaillou INSERM CIC1414 Rennes France

8. Sleep Department Polyclinique Rennes Saint‐Laurent Rennes France

9. Neurology Department University Hospital of Nantes, INSERM, CIC 1413 Nantes France

10. Clinical Neurophysiology Department University Hospital of Nantes, INSERM U1235, Nantes University Nantes France

11. Department of Neurology University Hospital of Strasbourg Strasbourg France

12. Genetic Institute and Molecular and Cellular Biology (IGBMC), INSERM‐U964/CNRS‐UMR7104/ Strasbourg University Illkirch France

13. AP‐HP, Salpetriere Hospital, DMU Neuroscience 6 Paris France

14. Sorbonne University, Paris Brain Institute, Inserm, CNRS Paris France

15. Adaptation Biologique et Vieillissement (UMR8256), Institut de Biologie Paris Seine, Sorbonne University, CNRS Paris France

Abstract

ABSTRACTBackgroundWe recently demonstrated in a randomized controlled trial (APOMORPHEE, NCT02940912) that night‐time only subcutaneous apomorphine infusion improves sleep disturbances and insomnia in patients with advanced Parkinson's disease and moderate to severe insomnia.ObjectivesTo identify the best candidates for receiving night‐time only subcutaneous apomorphine infusion in routine care.MethodsIn this post‐hoc analysis of APOMORPHEE, we compared the characteristics of patients according to whether they chose to continue night‐time only subcutaneous apomorphine infusion at the end of the study period or not.ResultsHalf of the patients (22/42) chose to continue the treatment. Off duration (day or night), painful Off dystonia, and insomnia severity at baseline were associated with night‐time only apomorphine continuation. Multivariate analysis retained only Off duration as an independent predictor of continuation.ConclusionsThe best candidates for night‐time only apomorphine are patients with severe and prolonged Off periods (day or night) and severe insomnia.

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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