7‐hydroxy‐staurosporine, UCN‐01, induces DNA damage response, and autophagy in human osteosarcoma U2‐OS cells

Author:

Lien Wei‐Chih12,Chen Ting‐Yu23,Sheu Shi‐Yuan45,Lin Tzu‐Chien2,Kang Fu‐Chi6,Yu Chung‐Hsing7,Kuan Ta‐Shen18,Huang Bu‐Miin29,Wang Chia‐Yih23ORCID

Affiliation:

1. Department of Physical Medicine and RehabilitationNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainanTaiwan

2. Department of Cell Biology and AnatomyCollege of MedicineNational Cheng Kung UniversityTainanTaiwan

3. Institute of Basic Medical SciencesCollege of MedicineNational Cheng Kung UniversityTainanTaiwan

4. School of MedicineChung Shan Medical UniversityTaichungTaiwan

5. Department of Integrated Chinese and Western MedicineChung Shan Medical University HospitalTaichungTaiwan

6. Department of AnesthesiaChi Mei Medical CenterChialiTainanTaiwan

7. Department of OrthopedicsChi Mei Medical CenterChialiTainanTaiwan

8. Department of Physical Medicine and RehabilitationCollege of MedicineNational Cheng Kung UniversityTainanTaiwan

9. Department of Medical ResearchChina Medical University HospitalChina Medical UniversityTaichungTaiwan

Funder

National Cheng Kung University Hospital

Ministry of Science and Technology, Taiwan

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference50 articles.

1. Present advances and future perspectives of molecular targeted therapy for osteosarcoma;Shaikh AB;Int J Mol Sci,2016

2. UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

3. UCN‐01 (7‐hydroxystaurosporine) inhibits DNA repair and increases cytotoxicity in normal lymphocytes and chronic lymphocytic leukemia lymphocytes;Yamauchi T;Mol Cancer Ther,2002

4. UCN-01, an anti-tumor drug, is a selective inhibitor of the conventional PKC subfamily

5. Apoptosis and the response to anticancer therapy

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