Effects of age, amyloid, sex, and APOE ε4 on the CSF proteome in normal cognition

Author:

Wesenhagen Kirsten E.J.1,Gobom Johan23,Bos Isabelle4,Vos Stephanie J.B.5,Martinez‐Lage Pablo6,Popp Julius78,Tsolaki Magda9,Vandenberghe Rik1011,Freund‐Levi Yvonne1213,Verhey Frans5,Lovestone Simon1415,Streffer Johannes1617,Dobricic Valerija18,Bertram Lars1819,Blennow Kaj23,Pikkarainen Maria20,Hallikainen Merja21,Kuusisto Johanna21,Laakso Markku21,Soininen Hilkka20,Scheltens Philip1,Zetterberg Henrik232223,Teunissen Charlotte E.24,Visser Pieter Jelle1512,Tijms Betty M.1,

Affiliation:

1. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam the Netherlands

2. Clinical Neurochemistry Lab, Institute of Neuroscience and Physiology Sahlgrenska University Hospital Mölndal Sweden

3. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology University of Gothenburg Mölndal Sweden

4. Nivel the Netherlands

5. Alzheimer Center Limburg, School for Mental Health and Neuroscience Maastricht University Maastricht the Netherlands

6. Center for Research and Advanced Therapies CITA‐Alzheimers Foundation Donostia‐San Sebastian Spain

7. Geriatric Psychiatry, Department of Mental Health and Psychiatry Geneva University Hospitals Geneva Switzerland

8. Department of Psychiatry University Hospital of Lausanne Lausanne Switzerland

9. 1st Department of Neurology, AHEPA University Hospital, Medical School, Faculty of Health Sciences Aristotle University of Thessaloniki Makedonia Thessaloniki Greece

10. Neurology Service University Hospitals Leuven Leuven Belgium

11. Laboratory for Cognitive Neurology, Department of Neurosciences KU Leuven Leuven Belgium

12. Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics Karolinska Institutet Stockholm Sweden

13. School of Medical Sciences Örebro University and Dep of Psychiatry Örebro University Hospital Örebro Sweden

14. Janssen‐cilag High Wycombe UK

15. (at the time of study conduct) University of Oxford Oxford UK

16. formerly Janssen R&D, LLC, Beerse, Belgium (at the time of study conduct) AC Immune SA Lausanne Switzerland

17. Department of Biomedical Sciences University of Antwerp Antwerp Belgium

18. Lübeck University Lübeck Germany

19. Center for Lifespan Changes in Brain and Cognition (LCBC), Department of Psychology University of Oslo Oslo Norway

20. Institute of Clinical Medicine, Neurology University of Eastern Finland Kuopio Finland

21. Institute of Clinical Medicine Internal Medicine and Kuopio University Hospital University of Eastern Finland Kuopio Finland

22. Department of Neurodegenerative Disease UCL Institute of Neurology London UK

23. UK Dementia Research Institute London UK

24. Neurochemistry Lab, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC Vrije Universiteit Amsterdam the Netherlands

Funder

Alzheimerfonden

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

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