Impact of undernutrition on the pharmacokinetics of chemotherapy in children with cancer: A systematic review-Reference-Cited by-同舟云学术

Impact of undernutrition on the pharmacokinetics of chemotherapy in children with cancer: A systematic review

Published:2023-07 Issue:9 Volume:70 Page:
ISSN:1545-5009
Container-title:Pediatric Blood & Cancer
language:en
Short-container-title:Pediatric Blood & Cancer

Author:

Schoon Sterre¹²^ORCID,Makamo Nthongase³⁴,Uittenboogaard Aniek¹⁵^ORCID,Bernhardt Melanie B.⁶,Ozuah Nmazuo W.⁴⁶,Kaspers Gertjan J. L.¹⁵,Huibers Minke H. W.¹⁵

Affiliation:

1. Princess Máxima Center for Pediatric Oncology Utrecht The Netherlands

2. Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands

3. Baylor College of Medicine Children's Foundation Lilongwe Malawi

4. Texas Children's Global Hematology‐Oncology‐Pediatric‐Excellence (HOPE) Program Lilongwe Malawi

5. Emma Children's Hospital, Amsterdam UMC Vrije Universiteit Amsterdam Pediatric Oncology/Global Child Health Group Amsterdam The Netherlands

6. Section of Hematology/Oncology Department of Pediatrics Baylor College of Medicine Houston Texas USA

Abstract

AbstractObjectivesThis systematic review provides an overview of the effect of undernutrition on the pharmacokinetics of chemotherapy in children with cancer.MethodsPubMed, Embase, and Cochrane were searched to identify eligible studies. This study uses the definition for undernutrition from the World Health Organization and the Gomez classification.ResultsFour studies with a total of 668 children with cancer were included and n = 121 (18%) were undernourished. Significant decreased clearance rates were found for vincristine in undernourished children compared to children with a normal nutritional status.ConclusionPresenting outcomes only show significant changes in the pharmacokinetics of vincristine in undernourished children with cancer. However, data are scarce, groups were small, and none of the studies included severely undernourished children. In order to improve outcomes for (severely) undernourished children with cancer, more pharmacokinetic research is needed. The ultimate goal would be to develop subgroups, and ultimately individualized drug dosing in order to improve outcomes for children with cancer worldwide.

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.30531

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